Document Details

Document Type : Article In Journal 
Document Title :
The alterations of rat brain GABA and glutamine induced by the organophosphorus compound cyolane. 1986.
التغيرات في مستويات الجابا والجلوتامين في مخ الجرذان المحدث بتائثير المبيد الفسفوعضوي " سيولين" (1986)
 
Subject : effect of organophosphate 
Document Language : English 
Abstract : Abstract: levels of the amino acids GABA and glutamate were determined in the whole brain of the white albino rat Rattus norvegicus after daily injection of 1/2,1/4,1/8, 1/16, 1/32 and 1/100 LD50 of cyolane. With 1/2 LD50 and increase in the level of both GABA and and glutamine in the brain was recorded. Dose levels of 1/4 and 1/8 LD50 caused an increase in the level of GABA and a decrease in glutamine concentration followed by an increase from the 7th and 11th day's for1/4 and 1/8 LD50, respectively. The induced increase in GABA level started from the 2nd week for 1/16 and 1/32 LD50 and from the 3rd week for 1/100 LD50 Dose levels of 1/32 and 1/100 LD50 caused a fluctuating increase in glutamine concentration starting from the 2nd,3rd and 6th weeks, respectively, which was followed by a fluctuating decrease at the 9th week for 1l32 and 1/100LD50 These findings support previous findings that the enhanced transformation of glutamic acid to GABA and glutamine is a result of disturbance in the metabolism of the glutamic acid-GABA and the glutamic acid-glutamine systems in the rat brain 
ISSN : 0306-492 
Journal Name : Comp. Biochem. Physiol. 
Volume : 85 
Issue Number : 2 
Publishing Year : 1407 AH
1986 AD 
Article Type : Article 
Added Date : Monday, December 27, 2010 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
سيد محمد راويRawi, sayed mohamedResearcherDoctoraterawisayed@yahoo.com

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