Document Details
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Document Type |
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Thesis |
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Document Title |
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"EVALUATION OF HYPOGLYCEMIC AND HYPOLIPIDEMIC EFFECTS OF EMBLICA OFFICINALIS FRUIT PULP AQUEOUS EXTRACT ON DIABETIC RATS" "تقييم التأثير الخافض للسكر والدهون في الدم للمستخلص المائي لثمرة الأملا على الجرذان المصابة بالسكري" |
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Subject |
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faculty of Human Sciences and Designs |
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Document Language |
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Arabic |
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Abstract |
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Objective: To evaluate the hypoglycemic and hypolipidemic potential of Emblica officinalis (EO) fruit aqueous extract on Type2 diabetic (T2D) rats with comparing to gliclazide (antidiabetic drug). Methods: The EO extract was assessed for the polyphenolic compounds pattern using liquid chromatography (LC), total phenolic and flavonoids contents, in addition to antioxidant activity by DPPH radical method. In vivo, the non-diabetic and streptozotocin (STZ)- nicotinamide induced diabetic rats were divided into seven groups (each group n=8) as follow (1) non-diabetic, (2) diabetic, (3) diabetic + gliclazide (10 mg/kg), (4) diabetic + gliclazide + EO low dose (200 mg/kg bw/d), (5) diabetic + gliclazide + EO high dose (400 mg/kg bw/d), (6) diabetic + EO low dose, and (7) diabetic + EO high dose. The EO and gliclazide were administrated orally for 8 weeks period. The glucose, insulin and glycol-hemoglobin (HbA1c) were assessed in rat serum. Subsequently, insulin resistance was calculated by homeostasis assessment model of insulin resistance (HOMA-IR). The lipid profile, reduced glutathione (GSH) and malondialdehyde (MDA) were also measured. Results: Significant increase in serum blood glucose, HbA1c, serum insulin (hyperinsulinemia), total cholesterol (T-Ch), triglycerides (TG) and low-density lipoprotein (LDL) levels that were significantly increased in T2D rats. Treatment with both high and low doses of EO significantly reduced the elevated levels of blood glucose, HbA1c, insulin, T-Ch, TG, and LDL-C in T2D rats. Furthermore, there was significant rise in HOMA-IR in T2D control rats whereas this was significantly prevented in T2D rats treated with EO. Both doses of EO exhibited significant decreased in MDA and significant increased in GSH levels in diabetic rats. Conclusion: The EO aqueous extract is effective in ameliorating hyperglycemia, hyperinsulinemia, insulin resistance, and hyperlipidemia in T2D rats. The anti-diabetic activity of EO aqueous extract showed a better potential than gliclazide, however, the treatment companied between EO and gliclazide was more efficient in most parameters. may be considered for further clinical studies in drug development. |
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Supervisor |
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Dr. Sahar Abdelgeyed Abdelziz |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1441 AH
2020 AD |
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Added Date |
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Wednesday, July 8, 2020 |
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Researchers
| أحلام محمد أربعين | Arbaeen, Ahlam Mohammed | Researcher | Master | |
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