Document Details
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Document Type |
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Thesis |
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Document Title |
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Effect of Doum (Hyphaene Thebaica) Fruit Water Extract on Hypercholesteremic Rats تأثير المستخلص المائي لفاكهة الدوم على الفئران المصابة بارتفاع كوليستيرول الدم |
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Subject |
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Faculty of Human Sciences and Designs |
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Document Language |
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Arabic |
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Abstract |
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Doum (Hyphaene thebaica) Water Extract (DWE) contains important bioactive compounds, such as phenolic and flavonoids, which helps to control hyperlipidemia. The study investigated the effect of DWE on hyperlipidemic rats in comparison with hypercholesterolemia medication (statin) during 4 weeks of treatment. Before animal experiment conducted, phenolic compounds of DWE identified and quantified using HPLC. The study used Fifty-six male albino rats (160 – 180 g) divided into (7) groups; each group consist of eight rats. Group (1 and 2) are control negative (-) and control positive (+) respectively. Group (2to 7) were fed with high cholesterol diet (HCD), Groups (3 ) given orally statins at amount of (40 mg / kg from body weight , Group ( 4to 7) were given orally(DWE) by gavage at two doses (20, 40mg/kg b. wt.) with or with out (w/wo) (statin) drug at dose (40 mg / kg b. wt.) respectively. Body weight gain % (BWG %), relative weight of liver, heart. lipid profile. antioxidant enzymes activity, as well as histopathological examination of liver and heart were tested. The results showed that, DWE contains 21 phenolic compounds. The total contents of phenolic and flavonoid values were (11.4 3 mg per GAE/g and 3. 48 mg per CE/g) respectively. After 4 weeks of treatments BWG percentage increased in rat fed with DWE (20, 40 mg/ kg) compare to control (+). Concerning DWE significantly (p<0.05) decrease lipid profile values compared to control (+). On the other hand, there is a significant (p<0.05) decrease in liver weight in DWE at two doses compared to control (+). The results showed a significant increase in antioxidant enzymes activity that helps to improve lipid peroxidation compared to control (+). Histopathology examination of hypercholesteremic rats revealed amelioration improvement in liver and heart in rats fed with DWE. The study clearly revealed that consumption of DWE might help to reduce high blood cholesterol in rats. Still, human studies are needed to confirm that the effect of Doum on hypercholesterolemic.
Key Words: Doum, Hyphaene Thebaica, Rats’, Hypercholesterolemic, Body Weight Cholesterol, Diet, Antioxidants, Lipid Profile, Statin, Flavonoid |
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Supervisor |
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Dr. |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1441 AH
2020 AD |
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Added Date |
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Saturday, June 6, 2020 |
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Researchers
| نسرين غازي الحربي | Al-harbi, Nisreen Ghazi Ghazi | Researcher | Master | |
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