Document Details
|
Document Type |
: |
Thesis |
|
Document Title |
: |
A study on the correlation of thyroid function and plasma lipid profile in ovariectomized female rats دراسة عن ارتباط وظائف الغدة الدرقية بمستوى الدهون في الدم في إناث الفئران التي استؤصلت مبايضها |
|
Subject |
: |
MEDICAL Physiology |
|
Document Language |
: |
Arabic |
|
Abstract |
: |
OBJECTIVES: To assess the association of thyroid function and lipid profile in ovariectomized rats, in addition to assessment of possible role of oxidative stress.
DESIGN: Thirty adult female rats weighing between (200-250 g) were used in the present study. Rats were randomly divided into two groups. Group I: 15 rats were subjected to bilateral ovariectomy and received no medications for the length of the protocol (16 weeks). Group II , Sham-operated control rats: 15 rats were subjected to the same surgical procedures of test group except for the bilateral ovariectomy. By the end of the 16th week, blood samples from all rats were collected through retro- orbital venous plexus and the obtained sera were subjected to the determination of estrogen, progesterone, T3, T4, TSH, total cholesterol, LDL-Cholesterol, HDL-Cholesterol, triglycerides as well as the total antioxidant activity. Atherogenic index, estrogen / progesterone ratio as well as the T4 / T3 ratio were calculated.
RESULTS: Bilateral ovariectomy for four months resulted in a significant decrease in the serum level of estrogen, progesterone, T3, HDL-Cholesterol, as well as the total antioxidant capacity, while the decrease in the TSH and triglycerides was insignificant. The comparison was made against the sham operated control rats. On the other hand the weight difference and the serum levels of T4, total-cholesterol as well as the LDL-Cholesterol were significantly increased. Correlation studies revealed that the significant positive correlation between T4 and T3 ( r: + 0.6632, P: < 0.05 ) in the control group was changed into insignificant positive ( r: + 0.4677, P: NS ) in response to bilateral ovariectomy indicating decreased conversion of T4 into the more potent T3. Also, the positive significant correlation between progesterone and T4 ( r: + 0.4883, P: < 0.05 ) in the sham operated control rats was changed into a negative significant correlation ( r: - 0.4846, P: < 0.05 ) in response to bilateral ovariectomy, indicating that the decrease in progesterone is associated with an increase in the level of T4.
CONCLUSION: Progesterone hormone promotes the conversion of T4 into the more potent T3. The decreased level of progesterone in response to bilateral ovariectomy could be the cause of the obtained hypothyroid state and its consequences. |
|
Supervisor |
: |
Prof.Dr. Hossam Awad |
|
Thesis Type |
: |
Master Thesis |
|
Publishing Year |
: |
1433 AH
2012 AD |
|
Co-Supervisor |
: |
Dr. Zienab Alrefaie |
|
Added Date |
: |
Wednesday, September 26, 2012 |
|
Researchers
| أسماء عبدالرحمن بخاري | Bukhari, Asma Abdulrahman | Researcher | Master | |
|
Back To Researches Page
|