Document Details
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Document Type |
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Thesis |
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Document Title |
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SECONDARY METABOLITES OF SOME ALGAL SPECIES FROM SAUDI RED SEA COAST نواتج الأيض الثانوية لبعض أنواع الطحالب من ساحل البحرالأحمرالسعودي |
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Subject |
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Faculty of Marine Sciences |
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Document Language |
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Arabic |
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Abstract |
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Marine organisms are potentially prolific sources of highly bioactive secondary metabolites that might represent useful leads in the development of new pharmaceutical agents. Red algae are considered as the most important source of many biologically active metabolites in comparison to other algal classes. Seaweeds are used for great number of applications by man. The principal use of seaweeds as a source of human food and as a source of gums (phycocollides). Phycocolloides like agar agar, alginic acid and carrageenan are primarily constituents of brown and red algal cell walls and are widely used in industry.
The Red Algae Laurencia papillosa from genus Laurencia (Ceramiales, Rhodomelaceae) has been established as source of secondary metabolites such as halogenated terpenes, C15 acetogenins and Steroids. Recently, researchers have described a wide range of biological activities for algal compounds including antibacterial, antifungal, and cytotoxic activities.
In this work, the Algae were collected from Saudi Red Sea coast (The Red Algae Lauarencia papillosa from Al-Shoaibah area south Jeddah).
Study the phytochemical screening of twelve marine algae representing three families for their alkaloids, flavonoids, sterols and/or triterpenoids, tannins and saponins. The results were reported in Table (4).
The red alga Laurencia papillosa was extracted and isolated through a series of chromatographic techniques. A combination of analytical chromatography, gas chromatography mass spectrometry (GC/MS) and nuclear magnetic resonance (NMR) analysis was necessary to identify the isolated compounds.
This study resulted in the isolation of fifteen compounds, three of which are new metabolites as (E)-2-(-1-hydroxy tridecyl)-2-heptadecenal (8) 3 β,7β-dihydroxy cholest-11-one (14) and 3α,6α-dihydroxy cholest-12-one (15). The other twelve compounds are known and identified as heptadecane (1), 2,10-dibromo-3-chloro-α-chamigrene (2), (E)-2-tridecyl-2-heptadecenal(3), (E)-2 dodecyl-2-hexadecenal(4), (E)-2-dodecyl-2-heptadecenal(5), (E)-2-tridecyl-2 nonadecenal (6), (E)-2-tridecyl-2-nonadecenal(7), an acetylinic compound cis-Laurencyne (9), phytol (10), cholesterol (11) cholestanol (12) and 24-methylene cholesterol (13). |
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Supervisor |
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Prof. Sultan S. Al-Lihaibi |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1431 AH
2010 AD |
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Co-Supervisor |
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Prof. Seif-Eldin N. Ayyad |
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Added Date |
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Sunday, July 25, 2010 |
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Researchers
| عصام عمر الوصابي | Al-Wesabi, Esam Omar | Researcher | Master | |
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