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Document Type |
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Thesis |
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Document Title |
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Effect of Carbamazepine (Tegretol) drug on the development of liver and ovary of the albino rat. تأثير عقار الكربامازبين (التجريتول)على نمو الكبد والمبيض في الجرذان البيضاء. |
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Subject |
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Sciences Faculty for Girls |
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Document Language |
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Arabic |
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Abstract |
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This study concerned with the effect of Carbamazepine on the morphogenesis and histogenesis of the ovary and liver of postnatal albino rat at (1-7-15-30-45-60) days old. In this study (90) mature albino rats were used, (60) female and (30) male. After meeting, the pregnant mothers were divided equally to (4) groups : control group and (3) treated groups, the first one were treated with acute single dose (3mg / rat) at (10th days) of gestation, the second group was treated with acute two doses, each dose was (3mg / rat) at (10th days) and (15th days) of gestation. The third group was treated with (20) chronic repeated doses (from the first day to the 20th – days of gestation) each dose was (1 mg / rat). The total generation was (635) from their (360) female were used. The morphological studies include malformation effects, difference of weights and heights were recorded . The ovaries and the liver were removed to be examined by histological studies using (3) different stains. Parts of liver at (30-days) old were fixated by gluteraldhyde for electron microscopic study. The results showed swelling at abdominal part in the most of treated groups, difference of weights and heights. The most affected group was that treated with two doses then with (20) chronic repeated doses. By light microscope, the ovaries were small in size and also delayed of their development. Decrease follicular cell degeneration and increase of presence of the apoptotic follicles and oedema of interstitial tissue. In the liver, the capsule was either reduced or thick, and spaces of blood sinusoids were congested and has a thick wall and deformed portal areas. There were degenerated cells of the selected organs, and some of necrotic tissue with pyknotic and karyorrhextic nuclei with vacuolated cytoplasm.
By electron microscope, the pyknotic and karyolitic nuclei with increase of vacuolated cytoplasm are seen. The changes mitochondria and fragmented rough endoplasmic reticulum, degeneration and deformed of bile canaliculi. From this study it was detected that, Carbamazepine induced harmful on the cells and tissues and the effects depend on the time and amount of the dose. We advise the pregnant mother to avoid intake of drugs during gestation and in case of medication it should yield to medical supervision. |
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Supervisor |
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prof. |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1431 AH
2010 AD |
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Added Date |
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Tuesday, June 29, 2010 |
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Researchers
| أحلام عباس هرساني | Harasani, Ahlam Abbas | Researcher | Master | |
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