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Document Type |
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Thesis |
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Document Title |
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Study on the efficacy of Garlic and Indinavir in the treatment of cryptosporidiosis in immunosu pressed rats تقييم كفاءة نبات الثوم وعقارإندينافير في علاج مرض الكريبتوسبوريديا في الجرذان المثبطة مناعيا |
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Subject |
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Sciences Faculty for Girls |
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Document Language |
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Arabic |
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Abstract |
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This study was done to evaluate the effect of immunosuppression on cryptosporidiosis in addition to evaluate the efficacy of garlic plant and indinavir drug in the treatment of cryptosporidiosis experimentally in immunosuppressed rat model. The evaluation was done through clinical , parasitological and histopathological studies at different days post infection p.i in addition to study the complete blood picture at 14th day p.i. The rats were divided into seven groups: normal control group (I), immunosuppressed control group (II), Indinavir control group (III), infected group(IV), immunosuppressed infected group (V), immunosuppressed infected group treated with garlic (VI) and immunosuppressed infected group treated with indinavir (VII). The results revealed that the intensity of infection was increased in immunosuppressed rat group . All of them had diarrhea, loss of appetite, weakness ,limited movement and weight gain was decreased , and the death rate was 51.4%. The infection rate was 100% and the number of excreted oocysts increased at different days p.i. The histopathological changes in the ileum were more severe in immunosuppressed group. There were significant decrease in Hb level , haematocrite percentage, total leucocytic count and lymphocyte percentage in immunosuppresed infected group in comparision to infected group. As regards to the treared groups, the results revealed that there was some improvement in both treated groups. Some of rats regained its activities and its weight. The death rate was 33.3% in indinavir treated group while in garlic treated group, there was no deaths. There was significantly decrease in the number of excreted oocysts at 5th day. and 10th day post treatment p.i. in both treated group. One week after the end of treatment the decreasing continued in garlic treated group while in indinavir treated group, the oocysts had increased .No cure rate was detected in both treated groups as the oocysts still excreted to the end of experiment. The histopathological changes had improved in both treated groups inspite of the presence of parasites on the epithelial surfaces of the ileum and presence of oedema in indinavir treated group. The total leucocytic count and lymphocyte percentage were significantly increased. So these results revealed that both garlic plant and indinavir drug had partial therapeutic efficacy in the treatment of cryptosporidiosis. |
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Supervisor |
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prof.Fawzia Hassan Toulah |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1431 AH
2010 AD |
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Added Date |
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Tuesday, June 22, 2010 |
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Researchers
| حياة سعود الرشيدي | Al-Rashidi, Hayat Saud | Researcher | Master | |
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