Document Details
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Document Type |
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Thesis |
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Document Title |
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Physicochemical Studies on Some Oxime Complexes Derived from Benzopyran, Pyridine, Pyrrole and their Biological Activity دراسات فيز يوكيميائية على بعض متراكبات الأوكسيمات المشتقة من البنزوبيران, البيريدين و البيرول ودراسة نشاطها البيولوجي |
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Subject |
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Sciences Faculty for Girls |
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Document Language |
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Arabic |
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Abstract |
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The biological importance of oximes and their complexes in minimizing glucose and lipid levels in blood, antidotal therapy in OP-induced brain damage, fat , and antiactiviy species against bacteria and fungi is well known. Thus, the present investigation report the preparation of new series of oxime, their Cu(II), Ni(II), Co(II), Mn(II), Zn(II), Fe(III), Cr(III) complexes and their Physicochemical & Biological Study.
The data reveled that the formed oxime under investigation and their metal complexes are stable mono, dinuclear, homo, heteronuclear depending on the reaction conditions. The formed complexes are yellow, green to black in color and they are insoluble in normal organic solvent but partially soluble in DMF and DMSO, decomposed at high temperature without melting indicating their polymeric nature.
The dissociation constant of HL4 and the stability constants of their Ni(II), Cu(II), Co(II), Mn(II) complexes in 75% dioxane-water at 25, 30, 35°C and I.S (0.0, 0.05, 0.1) were determined using pH metric titration.
The biological Activity of oximes HL4, HL7 and their complexes {21, 37, 38} against Aspergillus niger at 100 μg/mol indicated that. HL7 was stronger than HL4,and complex{38} was the strongest antifungel.
In this study, we demonstrated proximate effect of oxime L8 and its complex {41} on some biochemical parameters in serum of rats at high and low dose, which led to decrease in glucose and lipid levels compared with control group. |
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Supervisor |
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DR. |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1431 AH
2010 AD |
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Added Date |
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Monday, June 14, 2010 |
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Researchers
| نوره سالم الحبشي | AL-Hbshi, Nourah Salem | Researcher | Master | |
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