Document Details
|
Document Type |
: |
Thesis |
|
Document Title |
: |
Biochemical Effects Of Some Natural Antioxidants in Relation To CCl4 and NiCl2 Induction Hepato-Oxidative Injuries In Rats الـتأثيرات الكيموحيوية لبعض مضادات الأكسدة الطبيعية وعلاقتها بإصابات الأكسدة الكبدية المستحدثة برابع كلوريد الكربون وكلوريد النيكل في الجرذان |
|
Subject |
: |
Girls' College of Education in Jeddah |
|
Document Language |
: |
Arabic |
|
Abstract |
: |
The environmental pollutions are considered as one of the most prominent problems which most affecting countries over worldwide and focusing them to the greatest attention. The pollution is the major risk factors for enormous of diseases which burden all countries multi millions to safe peoples and to provide sufficient med care to prevent people from other diseases.
The effect of pollutants on the cells and tissues of living organism causes sort of damage lead to form free radicals in the body especially in te liver which plays an important role in protect the bodies from risk of pollution. Those various factors encouraging researcher to investigate and find out search the effectively treatment by using plants and other products to counteract various health problems and diseases in order to reduce the side effects of using manufactured drugs or natural plants and herbs.
In this research, three kinds of natural herbal extraction were chosen. They are Curcumin extracted from curcuma, Chlorophyllin which is sodium-copper salt of chlorophyll and mint oil extracted from filtration of Mentha piperita Linn (MPL). The previous extractions were used to treat poisoning caused by carbon tetrachloride and nickel chloride on experimental rats. The changes of the biochemical parameters in the serum and the liver tissues of rats, were studied.
The most important results obtained from the study can be summarized as following:-
Carbon tetrachloride and nickel chloride as known as poisoning agents which cause a great harms to the body cells and tissues and motivate the formation of free radicals and Lipid peroxidation. CCl4 is destroyed the respiratory chain inside mitochondria of the liver. NiCl2 bound to the Histone inside the nucleus, consequently, causes a defect in the genetic material.
The results of treatment by the three extractions, curcumin, chlorophyllin and mint oil showed an improvement in the activity of liver enzymes such as, Aspartate aminotransferase, Alanine Aminotransferase, Alkaline Phosphatase and in the levels of Total bilirubin, creatinine, urea, and uric acid and a variation of total protein in the serum.
Treatment is also showed an increase in the activity of antioxidants enzymes such as, Catalase, Superoxide dismutase, Glutathion Peroxidase, and Glutathion Reductase, which showed decreasing in the activity of malondialdehyde and a variation in the total protein of the liver. The results were obtained in the study emphasized by the histological examination of liver tissues in the various groups.
These results emphasize the effective role of these extractions as antioxidants able to improve and rebuilding the damage cells that might occur because of various pollutants. Also they are able to motivate the immune systems in the body and protect proteins and nucleic acids. They also able to scavenge the free radicals from the body by increasing the activity of natural antioxidants.
This study were focused on the effect of these extractions of curcumin, chlorophyllin and mint oil as natural antioxidants to release the body from harmful free radicals, the damage cells and tissues and many induced diseases that might injure the living organs.
The conclusion of the study recommends the following :-
• Using the three extractions ,curcumin, chlorophyllin and mint oil as treatment and protection agents from environmental pollutants and diseases.
• An extra intensive research and studies are required to understand the mechanism and mode of action of these naturally antioxidants and their efficacy on the target cells and as a potent antioxidants able to protect cells and tissues from the oxidative damage exerted daily by various environmental pollutants. |
|
Supervisor |
: |
dr.Nadia Amine Abdulmajed |
|
Thesis Type |
: |
Doctorate Thesis |
|
Publishing Year |
: |
1430 AH
2009 AD |
|
Added Date |
: |
Wednesday, December 30, 2009 |
|
Researchers
| حنان سعيد النهدي | AL-Nahdi, Hanan Saeid | Researcher | Doctorate | |
|
Back To Researches Page
|