Document Details

Document Type : Project 
Document Title :
Effect of maternal lead exposure on the fetal development and the role of antioxidant therapy. “Experimental study in rats”
تأثير تعرض الأم لعنصر الرصاص أثتاء الحمل علي نمو الجنين و دور العلاج بمضادات الأكسدة. دراسة تجريبية في الفئران
 
Subject : Effect of maternal lead exposure on the fetal development and the role of antioxidant therapy. “Experimental study in rats” 
Document Language : Arabic 
Abstract : Lead pollution is a widespread environmental problem in both developing and industrialized countries. The persistence of lead in the humans and animals and the associated health risk becomes a topic of current debate and concern. Lead has been found to produce wide range of toxic biochemical effects, besides behavioral dysfunction in man and in experimental animals. Lead, also, was found to have an extensive history as a reproductive toxin, which exerts its effect either directly on the developing fetus after gestation begins, or indirectly on paternal or maternal physiology before and during the reproduction process. Although several studies have been conducted in order to investigate the association between undue lead exposure and sterility, abortion, stillbirths, and neonatal deaths, a very limited evidence and conflicting results was available about the detailed embryotoxic effects of prenatal lead exposure of pregnant women and as to whether long exposure to subtoxic levels of lead affect fertility or cause fetal injuries in humans. Moreover, although several mechanisms have been proposed to explain the lead-induced toxicity, no mechanisms have been yet defined explicitly. Recent studies suggest oxidative stress as one of the important mechanisms of toxic effects of lead. These recent findings suggest potential role of antioxidants to ameliorate lead toxicity 
Publishing Year : 1428 AH
2007 AD 
Sponsor Name : King Abdulaziz Univeristy 
Sponsorship Year : 1428 AH
2007 AD 
Added Date : Monday, June 28, 2010 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
حامد عبد الرؤوف صالحSaleh, Hamid AbdulraoofInvestigatorDoctorate 

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 27168.docx docx 

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