Document Details

Document Type : Project 
Document Title :
Maternal biochemical markers and maternal fetal nucleic acids for screening of fetal aneuploidy and adverse pregnancy outcomes: a prospective study
استخدام الواسمات الكيموحيوية والأحماض النووية الجينية الأمومية للتعرف على اختلاطات الحمل ونتائجه المعاكسة
 
Subject : Maternal biochemical markers and maternal fetal nucleic acids for screening of fetal aneuploidy and adverse pregnancy outcomes: a prospective study 
Document Language : Arabic 
Abstract : There are several prenatal screening programmes currently in practice in both Europe and North America using maternal biochemical markers and ultrasonography. Several studies have reported racial differences in the use of such markers and investigators reported differences between Caucasian and Asian populations. Unfortunately, no information is available in the literature in relation to the use of these markers during the course of prenatal care in Saudi Arabian population. Recently, molecular analysis of plasma nucleic acids during human pregnancy has led to the discovery that maternal plasma contains both fetal DNA and fetal RNA. The detection of fetal nucleic acids in maternal plasma is much simpler and more robust than detecting fetal nucleated cells in maternal blood, and does not require prior enrichment. This approach may also have application in the prenatal diagnosis of fetal abnormalities and/or adverse pregnancy outcomes. Thus, the main objectives of the present proposed research project are to establish, in the local population of pregnant women, the reference values of first and second trimesters biochemical markers [namely: α-fetoprotein (AFP), unconjugated oesteriol (uE3), human chorionic gonadotrophin (hCG), free β-hCG, inhibin-A (In-A), pregnancy associated plasma protein-A (PAPP-A) and fetal nuchal translucency thickness (fetal-NT) together with that of maternal fetal DNA and fetal RNA used for prenatal screening of fetal aneuploidies and other adverse pregnancy outcomes. In addition, the value of such markers and the efficacy of their use in relation to adverse pregnancy outcomes in the local population will also be evaluated. The duration of this project is 20 months. 
Publishing Year : 1428 AH
2007 AD 
Sponsor Name : King Abdulaziz University 
Sponsorship Year : 1428 AH
2007 AD 
Added Date : Sunday, June 27, 2010 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
محمد العرضاوي صالح العرضاويAl-Ardaw, Mohammed ٍSalehInvestigatorDoctorate 

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