Document Details

Document Type : Thesis 
Document Title :
Effect of camphor on the embryos and uterus histology of the rats during pregnancy
تأثير الكافور على الأجنة والتركيب النسيجي لرحم الجرذان أثناء الحمل
 
Subject : Mice - Physiology 
Document Language : Arabic 
Abstract : Camphor has long been used in dead bodies wash in Saudi Arabia and in many of the medical products for the treatment and is extensively used in pharmaceutical preparations and skin care products. Experiments were conducted to study the effect of camphor on embryos and uterus histology pregnant rat Sprague–Dawley. Pregnant rats (n=40) were divided into 4 groups (n=10); 3 treated groups were given intraperitoneal injection by different doses of water camphor solution (5,10 and 20mg camphor/kg body weight); the control group was given the same doses of saline. All groups were kept in constant temperature rooms (22±2 ◦C) and 12 h light/12 h dark photoperiod. At the end of week first and second of gestation, 3 animals from each group and 4 at the end of third week were anesthetized, their blood, embryos and uterus were obtained. The results showed a significant increase in the average body weight of pregnant rats in the first week of gestation for G2 (10 mg/kg), and in the second week of gestation for G3 (20mg/kg) compared to the control group, while third week of gestation, showed no significant difference. The hormonal analysis for estrogen and progesterone did not show significant difference with all used doses. A significant decrease in fetal body length and weight were recorded. Also, there were increase in both number of dead embryos, distortions and incomplete growth in animals injected with (20mg/kg).We observed alterations in uterine architecture including degeneration and change in the shape of epithelial cells, appearance of clear lucid inside the cytoplasm and dilatation of blood vessels. In group injected with (20mg/kg), there were increases in both size and number of blood vessels with cellular infiltration. The present study showed that camphor might had a negative impact on the uterus tissue and embryos, so we advised to be care for the usage of camphor especially with pregnant female. 
Supervisor : sabah Abdul Aziz Linjawi 
Thesis Type : Master Thesis 
Publishing Year : 1431 AH
2010 AD 
Number Of Pages : 152 
Added Date : Wednesday, October 30, 2013 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
ابتسام عبد الله الحبابيAl-Hababi, Ebtesam AbdullahResearcherMaster 

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 36215.pdf pdf 
 36216.pdf pdf 

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