Document Details

Document Type : Article In Journal 
Document Title :
leishmania donouani is the only cause of visceral leishmaniasis in east africa previous descriptions of L.
الليشمانيا donouani هو السبب الوحيد لداء الليشمانيات الحشوي في شرق أفريقيا الأوصاف السابقة من L.
 
Subject : leishmania donouani is the only cause of visceral leishmaniasis in east africa previous descriptions of L. 
Document Language : English 
Abstract : Isoenzyme-based studies have identified 3 taxa/species/‘phylogenetic complexes’ as agents of visceral leishmaniasis in Sudan: L. donovani, L. infantum and ‘‘L. archibaldi’’. However, these observations remain controversial. A new chitinase gene phylogeny was constructed in which stocks of all 3 putative species isolated in Sudan formed a monophyletic clade. In order to construct a more robust classification of the L. donovani complex, a panel of 16 microsatellite markers was used to describe 39 stocks of these 3 species. All ‘‘L. donovani complex’’ stocks from Sudan were again found to form a single monophyletic clade. L. donovani ss stocks from India and Kenya were found to form 2 region-specific clades. The partial sequence of the glutamate oxaloacetate transaminase (GOT) gene of 17 L. donovani complex stocks was obtained. A single nucleotide polymorphism in the GOT gene appeared to underlie the isoenzyme classification. It was concluded that isoenzyme-based identification is unsafe for stocks isolated in L. donovani endemic areas and identified as L. infantum. It was also concluded that the name L. archibaldi is invalid and that only a single visceralizing species, Leishmania donovani, is found in East Africa. 
ISSN : 1432-1955 
Journal Name : Parasitology 
Volume : 129 
Issue Number : 1 
Publishing Year : 1424 AH
2004 AD 
Article Type : Article 
Added Date : Tuesday, March 5, 2013 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
منال بكر جمجومJamjoom, Manal BakrResearcherDoctoratemjamjoom@kau.edu.sa

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