Document Details

Document Type : Article In Journal 
Document Title :
In Vitro Antitrichomonal Effect of Nigella Sativa Aqueous Extract and Wheat Germ Agglutinin
In Vitro Antitrichomonal Effect of Nigella Sativa Aqueous Extract and Wheat Germ Agglutinin
 
Subject : Medical Parasitology 
Document Language : English 
Abstract : Trichomoniasis is one of the most common parasitic sexually transmitted diseases in the world. Metronidazole was known as the most effective drug for human trichomoniasis; however, drug resistance and toxicity appeared. This study was designed to investigate the in vitro inhibitory activity of wheat germ agglutinin and Nigella sativa aqueous extract on the growth and motility of Trichomonas vaginalis in comparison to metronidazole. The inhibitory effect was dose related. Minimal lethal concentration of wheat germ agglutinin was 250 µg 250µg/ml in all incubation periods. Minimal lethal concentration of metronidazole was 50 µg 50 µg/ml after 24 hours. However, lower doses of metronidazole showed a minimal lethal concentration of 25 µg 25 µg/ml after 48 hours and 12 µg 12 µg/ml after 72 hours of incubation; whereas, lower doses of wheat germ agglutinin failed to completely inhibit the parasite growth. Although N. sativa aqueous extract had the lowest effect on parasite growth, producing a lethal effect only after 48 hours, it still has a remarkable effect. All drugs remarkably inhibited the motility of the trophozoites. The results showed a promising effect of using wheat germ agglutinin and N. sativa aqueous extract in treating T. vaginalis infection 
ISSN : 1319-1004 
Journal Name : Medical Science Journal 
Volume : 16 
Issue Number : 2 
Publishing Year : 1430 AH
2009 AD 
Article Type : Article 
Added Date : Wednesday, October 5, 2011 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
عبدالقادر تنكلTonkal, AbdulKader ResearcherDoctorate 

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