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Document Type |
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Article In Journal |
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Document Title |
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Medical conditions associated with a positive anti-double-stranded deoxyribonucleic acid Medical conditions associated with a positive anti-double-stranded deoxyribonucleic acid |
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Subject |
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Rheumatology |
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Document Language |
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English |
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Abstract |
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OBJECTIVE:
To explore the associated diseases with positive anti-double stranded (ds) DNA other than systemic lupus erythematosus (SLE), and to determine an association if any, between its level in non-SLE causes.
METHODS:
This is a retrospective review of all patients with positive anti-dsDNA assay (more than 200 IU/ml) tested for any underlying etiology from January to December 2007 at King Abdul-Aziz University Hospital, Jeddah, Kingdom of Saudi Arabia.
RESULTS:
Two hundred and twelve patients with anti-dsDNA antibody testing were evaluated. Of these, 124 patients had SLE (58.5%), while 88 patients (41.5%) had other diseases. Representing non-SLE diseases were: rheumatological disorders in 29 patients (33%), infections in 11 (12%), and malignancy in 6 patients (7%). Strong positive results (>800 IU/ml) were found in only 8 patients (4%) with diagnoses of antiphospholipid antibody syndrome, tuberculosis, osteomylitis, thymoma, lymphoma, sarcoidosis, and 2 autoimmune hepatitis patients. There was a statistically significant association between highly positive anti-dsDNA testing and rheumatological disorders.
CONCLUSION:
Although positive anti-dsDNA test is common in SLE patients, other diseases should be considered when the anti-dsDNA level is equivocal, and the clinical criteria are not in favor of SLE |
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ISSN |
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0379-5284 |
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Journal Name |
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The Saudi Medical Journal |
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Volume |
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31 |
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Issue Number |
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7 |
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Publishing Year |
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1431 AH
2010 AD |
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Article Type |
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Article |
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Added Date |
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Sunday, August 14, 2011 |
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Researchers
| سوزان عطار | Attar, Suzan | Investigator | Doctorate | |
| عماد كوشك | Koshak, Emad | Researcher | Doctorate | |
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