Document Details

Document Type : Article In Journal 
Document Title :
A Comparison Study of Radiotherapy Toxicity between Conventional and Hypofractionated Whole Breast Radiotherapy
A Comparison Study of Radiotherapy Toxicity between Conventional and Hypofractionated Whole Breast Radiotherapy
 
Subject : Radiation Therapy 
Document Language : English 
Abstract : The aim is to compare the acute skin toxicity between two different fractionation schedules of adjuvant whole breast radiotherapy, conventional fractionation radiotherapy and hypofractionated radiotherapy. This is a prospective study of breast cancer patients referred for adjuvant radiation therapy. Radiation therapy was given either as conventional fractionation radiotherapy (5000 cGy/ 25 fractions / 5 weeks) or hypofractionated radiotherapy (4005 cGy/15 fractions / 3 weeks). Acute RT toxicity was evaluated using the Radiation Therapy Oncology Group toxicity grading system; the incidence of radiation therapy toxicity was compared. Seventy-eight patients were accrued in the study, 58% had breast conservative surgery and 42% had modified radical mastectomy. 54% were treated with hypofractionated radiotherapy and 46% with conventional fractionation radiotherapy, while 64% had Grade 0-II radiation therapy toxicity and 36% had Grade III-IV toxicity. On univariate analysis, the incidence of radiation therapy toxicity was (52.8%) in conventional fractionation radiotherapy group as compared to 21.4% in hypofractionated radiotherapy group (p = 0.004); other variables were not statistically significant. On multivariate analysis radiotherapy fractionation was the only factor of statistical significance regarding the incidence of radiation reaction (p = 0.03). This study showed fewer incidences of acute radiation reactions in hypofractionated arm as compared to conventional fractionated arm in the adjuvant whole breast radiotherapy 
ISSN : 1319-1004 
Journal Name : Medical Science Journal 
Volume : 17 
Issue Number : 3 
Publishing Year : 1431 AH
2010 AD 
Article Type : Article 
Added Date : Wednesday, April 13, 2011 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
ياسر بهادرBahadur, Yasir ResearcherDoctorate 

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