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Document Type |
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Thesis |
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Document Title |
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CUBOSOMAL HYDROGEL FOR TRANSDERMAL DELIVERY OF AN ANTI-INFLAMMATORY DRUG جسيمات مكعبة في هلام مائي لتوصيل عقار مضاد للالتهابات عبر الجلد |
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Subject |
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faculty of Pharmacy |
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Document Language |
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Arabic |
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Abstract |
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Lornoxicam is a potent non-steroidal anti-inflammatory drug that is used commonly as analgesic and inti-inflammatory in various conditions. Nevertheless, it has a short half-life (3-4 h) along with gastric side effect upon oral administration. Therefore, objective of this work is to conquer the aforementioned limitations by developing an optimized lornoxicam cubosomal dispersion loaded hydrogel with improved transdermal permeation. Lornoxicam cubosomal dispersion were prepared according to Box-Behnken experimental design. The impact of formulation variables 1-Oleoyl-rac-glycerol (GMO), Poloxamer 407 (PLX), and Polyvinyl alcohol (PVA) in the ranges of 4-12%, 0.5-1%, and 0-0.5% w/w, respectively, on particle size, zeta potential, entrapment efficiency and release efficiency were evaluated. The optimized formula was subjected to transmission electron microscope and differential scanning calorimetry analysis, then loaded in Carbopol® 940 based hydrogel to prepare optimized lornoxicam cubogel. The prepared gel characterized for pH, rheology, in vitro release, ex vivo permeation and in vivo pharmacokinetics in Wistar rats. Successfully, optimized lornoxicam cubogel showed two-fold enhancement in cumulative amount permeated across rat skin relative to conventional gel. Furthermore, in vivo assessment revealed significant higher bioavailability of optimized lornoxicam cubogel compared to oral tablet. These results propose that cubosomes based hydrogel could be regarded as efficient vehicle for transdermal drug delivery. |
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Supervisor |
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Prof. Hibah Mubark Aldawsari |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1442 AH
2020 AD |
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Co-Supervisor |
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Prof. Shaimaa Mohamed Badr-Eldin |
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Added Date |
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Friday, December 25, 2020 |
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Researchers
| أمل عبدالله الدخيل | Aldakheel, Amal Abdullah | Researcher | Master | |
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