Document Details

Document Type : Thesis 
Document Title :
EFFECT OF CO-ENZYME Q10 ON LIVER INJURY INDUCED BY VALPROIC ACID AND ITS ANTIEPILEPTIC ACTIVITY IN RATS
تأثير كو انزايم Q10 على اصابة الكبد الناجم عن استخدام حمض الفالبرويك وفاعليته لعلاج الصرع في الجرذان المصابة بالصرع
 
Subject : Faculty of medicine 
Document Language : Arabic 
Abstract : BACKGROUND AND AIM: Valproic acid (VPA) has toxic metabolite which can elevate oxidative stress markers and reduces the anti-oxidative system. Hepatotoxicity of VPA had been reported. Coenzyme Q10 (CoQ10) is one of a widest used antioxidant. The present study was conducted to study the effect of Co Q10 on epileptogenesis process in comparison to valproic acid using the rats' model of pentylenetetrazole (PTZ) induced kindling, in addition to evaluating the effect of CoQ10 on VPA hepatotoxicity. METHODS: Rats were divided into 5 groups: Control group: received vehicle for VPA and CoQ10 by oral gavage daily and saline by IP injection three times weekly for 60 days. Positive group: received vehicle for VPA and CoQ10 as above and 30 mg/kg of PTZ IP injection three times weekly for 60 days. VPA group received 500 mg/ kg of valproic acid by oral gavage daily and PTZ as above for 60 days. CoQ10 group: received 200mg/ kg of CoQ10 by oral gavage daily and, PTZ as above for 60 days. VPA and CoQ10 group: received VPA, CoQ10 and, PTZ as above for 60 days. RESULTS: CoQ10 exhibited anticonvulsant activity and potentiated anticonvulsant effect of VPA. Combination of CoQ10 with VPA induced a greater reduction in oxidative stress, improvement in the histopathological changes in brain and liver compared to VPA treatment. CONCLUSION: These findings suggest that co-administration of CoQ10 with VPA in epilepsy might be a therapeutic potential in increasing the efficacy and reducing the hepatotoxicity of VPA. Keywords: Pentylenetetrazole, Valproic acid, CoQ10, Glutathione, Malondialdehyde, Protein Carbonyl, reactive oxygen species. 
Supervisor : Prof. Hala Salah Abd El-Kawy Eweis 
Thesis Type : Master Thesis 
Publishing Year : 1441 AH
2020 AD 
Added Date : Tuesday, May 26, 2020 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
فهد محمد القرنيAlqarni, Fahad Alqarni MohammedResearcherMaster 

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 46213.pdf pdf 

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