Document Details

Document Type : Thesis 
Document Title :
Design and Development of Vaginal Insert of Antifungal Drug
تصميم وتطوير عقار مضاد للفطريات على صيغة ادراج مهبلي
 
Subject : faculty of Pharmacy 
Document Language : Arabic 
Abstract : Fluconazole, used orally for vaginal candidiasis, has reported gastrointestinal side effects. Therefore, researchers directed towards the drug vaginal delivery. However, vaginal delivery is limited by poor retention and leakage. Thus, this work aimed at exploring chitosan/anion polyelectrolyte complex (PEC) for the formulation of Fluconazole vaginal inserts with controlled release and appreciable mucoadhesion. PECs were prepared and assessed for interactions. Fluconazole PEC based vaginal inserts were prepared by lyophilization using mannitol. 3151 factorial design was applied to investigate the effect of the anion type and CH/anion ratio on the inserts mucoadhesion and release properties. The optimized insert [based on 5:5 CH: anionic polymer (sodium alginate)] release was modulated by the release retardant; Compritol® 888. The selected formulation was subjected to microbiological and histological evaluation. Fluconazole inserts showed satisfactory drug content, acceptable friability percentages and highest swelling indices at six hours. Statistical analysis showed significant effect of the studied factors on detachment force and release properties. Microbiological assays revealed significantly higher antifungal activity of inserts compared to Fluconazole solution. Reduced inflammatory cells were confirmed by histological evaluation. CH/Alg based vaginal insert could be a promising platform for vaginal delivery of antifungal drugs used for vaginal candidiasis treatment. Keywords: Fluconazole; chitosan; alginate; lyophilization; polyelectrolyte complex; vaginal; microbiology; histology. 
Supervisor : Dr. Hibah Aldawsari 
Thesis Type : Master Thesis 
Publishing Year : 1440 AH
2019 AD 
Co-Supervisor : Dr. Shaimaa Mohamed Badr-Eldin 
Added Date : Sunday, July 14, 2019 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
بيان درويشDarwesh, Bayan ResearcherMaster 

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