Document Details

Document Type : Thesis 
Document Title :
DIAGNOSTIC SIGNIFICANT OF CA27.29 AND CA 15.3 IN SAUDI BREAST CANCER PATIENT
اهمية CA15.3 و CA27.29 في تشخيص حالات سرطان الثدي في المرضي السعوديين
 
Subject : Faculty of medicine 
Document Language : Arabic 
Abstract : Background and Aim: Non-alcoholic fatty liver diseases (NAFLD) is a term that describes liver diseases that affect people who drink little or no alcohol. These diseases could cause severe damage to the liver. The most common causes are obesity, insulin resistant and cytokines. It’s important to find noninvasive marker for the detection of the earlier stages. TNFα and IL-6 are cytokines that are suggested to contribute in NAFLD pathogenesis. This study aims to find a relationship between NAFLD and biomarkers of cytokines tumor necrosis factor α and interleukin 6. Method: In this case control study of total 38 patients were diagnosed and confirmed by the fibroScan® at King Abdul-Aziz University Hospital in Jeddah, Saudi Arabia. We obtained the clinical data and measured serum TNFα and IL-6, Biochemical markers and correlate patients with 8 control subjects matched in age and sex. Result: TNF-α was higher in advanced steatosis than simple steotosis (25.44±7.89 pmol/L vs. 22.48±5.97 pmol/L) compared to control (20.29 ± 0.49 pmol/L), however, there was no significant difference between patients and control (P = 0.23). IL-6 showed a significant difference between advanced steatosis and simple steatosis (17.883±22.0341 pmol/L vs. 7.07±1.79 pmol/L) compared to control (5.813±1.886 pmol/L) with (P  .012). Conclusion: This study showed that the inflammatory mediators TNF-α and IL-6 levels were related to the presence of NAFLD/NASH that is comparable to the finding by other researches. The levels were higher in NAFLD group than control. However, only IL-6 level showed a significant association with the severity of hepatocyte inflammation, stage of fibrosis and systemic IR in patient with NASH. 
Supervisor : Dr. Fayez Fawaz Al Fayez 
Thesis Type : Master Thesis 
Publishing Year : 1440 AH
2018 AD 
Added Date : Monday, November 19, 2018 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
جواهر طه الحربيAlharbi, Jawaher TahaResearcherMaster 

Files

File NameTypeDescription
 43825.pdf pdf 

Back To Researches Page