Document Details

Document Type : Article In Journal 
Document Title :
Colorectal carcinogenesis, radiation quality, and the ubiquitin-proteasome pathway
Colorectal carcinogenesis, radiation quality, and the ubiquitin-proteasome pathway
 
Document Language : English 
Abstract : Adult colorectal epithelium undergoes continuous renewal and maintains homeostatic balance through regulated cellular proliferation, differentiation, and migration. The canonical Wnt signaling pathway involving the transcriptional co-activator β-catenin is important for colorectal development and normal epithelial maintenance, and deregulated Wnt/β-catenin signaling has been implicated in colorectal carcinogenesis. Colorectal carcinogenesis has been linked to radiation exposure, and radiation has been demonstrated to alter Wnt/β-catenin signaling, as well as the proteasomal pathway involved in the degradation of the signaling components and thus regulation of β-catenin. The current review discusses recent progresses in our understanding of colorectal carcinogenesis in relation to different types of radiation and roles that radiation quality plays in deregulating β-catenin and ubiquitin-proteasome pathway (UPP) for colorectal cancer initiation and progression. 
ISSN : 107-150 
Journal Name : Journal of cancer 
Volume : 7 
Issue Number : 2 
Publishing Year : 1437 AH
2016 AD 
Article Type : Article 
Added Date : Tuesday, July 11, 2017 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Kamal DattaDatta, Kamal ResearcherDoctorate 
Shubhankar SumanSuman, Shubhankar ResearcherDoctorate 
Santosh KumarKumar, Santosh ResearcherDoctorate 
Albert J Fornace Jr.Fornace Jr., Albert J ResearcherDoctorate 

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