Document Details

Document Type : Article In Journal 
Document Title :
Transcriptomics profiling study of breast cancer from Kingdom of Saudi Arabia revealed altered expression of Adiponectin and Fatty Acid Binding Protein4: Is lipid metabolism associated with breast cancer?
Transcriptomics profiling study of breast cancer from Kingdom of Saudi Arabia revealed altered expression of Adiponectin and Fatty Acid Binding Protein4: Is lipid metabolism associated with breast cancer?
 
Document Language : English 
Abstract : BACKGROUND: Breast cancer incidence rates are increasing at an alarming rate among Saudi Arabian females. Most molecular genetic discoveries on breast cancer and other cancers have arisen from studies examining European and American patients. However, possibility of specific changes in molecular signature among cancer patients of diverse ethnic groups remains largely unexplored. We performed transcriptomic profiling of surgically-resected breast tumors from 45 patients based in the Western region of Saudi Arabia using Affymetrix Gene 1.0 ST chip. Pathway and biological function-based clustering was apparent across the tissue samples. RESULTS: Pathway analysis revealed canonical pathways that had not been previously implicated in breast cancer. Biological network analysis of differentially regulated genes revealed that Fatty acid binding protein 4, adipocyte (FABP4), adiponectin (ADIPOQ), and retinol binding protein 4 (RBP4) were most down regulated genes, sharing strong connection with the other molecules of lipid metabolism pathway. The marked biological difference in the signatures uncovered between the USA and Saudi samples underpins the importance of this study. Connectivity Map identified compounds that could reverse an observed gene expression signature CONCLUSIONS: This study describes, to our knowledge, the first genome-wide profiling of breast cancer from Saudi ethnic females. We demonstrate the involvement of the lipid metabolism pathway in the pathogenesis of breast cancer from this region. This finding also highlights the need for strategies to curb the increasing rates of incidence of this disease by educating the public about life-style risk factors such as unhealthy diet and obesity. 
ISSN : 1471-2164 
Journal Name : BMC Genomics 
Volume : 16 
Issue Number : 1 
Publishing Year : 1436 AH
2015 AD 
Article Type : Article 
Added Date : Monday, April 25, 2016 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Adnan MerdadMerdad, Adnan Investigator  
Sajjad KarimKarim, Sajjad Researcher  
Hans-Juergen SchultenSchulten, Hans-Juergen Researcher  
Manikandan JayapalJayapal, Manikandan Researcher  
Ashraf DallolDallol, Ashraf Researcher  
Abdelbaset BuhmeidaBuhmeida, Abdelbaset Researcher  
FATIMA AL-THUBAITYAL-THUBAITY, FATIMA Researcher  
Mamdooh A GariGari, Mamdooh AResearcher  
Adeel GA ChaudharyChaudhary, Adeel GAResearcher  
Adel M AbuzenadahAbuzenadah, Adel MResearcher  
Mohammed H Al-QahtaniAl-Qahtani, Mohammed HResearcher  

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