Document Details

Document Type : Article In Journal 
Document Title :
Coordinated effects of sequence variation on DNA binding, chromatin structure, and transcription
Coordinated effects of sequence variation on DNA binding, chromatin structure, and transcription
 
Document Language : English 
Abstract : DNA sequence variation has been associated with quantitative changes in molecular phenotypes such as gene expression, but its impact on chromatin states is poorly characterized. To understand the interplay between chromatin and genetic control of gene regulation, we quantified allelic variability in transcription factor binding, histone modifications, and gene expression within humans. We found abundant allelic specificity in chromatin and extensive local, short-range, and long-range allelic coordination among the studied molecular phenotypes. We observed genetic influence on most of these phenotypes, with histone modifications exhibiting strong context-dependent behavior. Our results implicate transcription factors as primary mediators of sequence-specific regulation of gene expression programs, with histone modifications frequently reflecting the primary regulatory event. 
ISSN : 0036-8075 
Journal Name : Science 
Volume : 342 
Issue Number : 6159 
Publishing Year : 1434 AH
2013 AD 
Article Type : Article 
Added Date : Monday, April 4, 2016 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Helena KilpinenKilpinen, Helena Researcher  
Sebastian M WaszakWaszak, Sebastian M Researcher  
Andreas R GschwindGschwind, Andreas R Researcher  
Nouria HernandezHernandez, Nouria Investigator  
Alexandre ReymondReymond, Alexandre Investigator  
Bart DeplanckeDeplancke, Bart Investigator  
Emmanouil T. DermitzakisDermitzakis, Emmanouil T. Investigator  

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