Document Details

Document Type : Article In Journal 
Document Title :
Type 2 innate lymphoid cells drive CD4+ Th2 cell responses
Type 2 innate lymphoid cells drive CD4+ Th2 cell responses
 
Document Language : English 
Abstract : CD4(+) T cells have long been grouped into distinct helper subsets on the basis of their cytokine-secretion profile. In recent years, several subsets of innate lymphoid cell have been described as key producers of these same Th-associated cytokines. However, the functional relationship between Th cells and innate lymphoid cells (ILCs) remains unclear. We show in this study that lineage-negative ST2(+)ICOS(+)CD45(+) type 2 ILCs and CD4(+) T cells can potently stimulate each other's function via distinct mechanisms. CD4(+) T cell provision of IL-2 stimulates type 2 cytokine production by type 2 ILCs. By contrast, type 2 ILCs modulate naive T cell activation in a cell contact-dependent manner, favoring Th2 while suppressing Th1 differentiation. Furthermore, a proportion of type 2 ILCs express MHC class II and can present peptide Ag in vitro. Importantly, cotransfer experiments show that type 2 ILCs also can boost CD4(+) T cell responses to Ag in vivo. 
ISSN : 0022-1767 
Journal Name : The Journal of Immunology 
Volume : 192 
Issue Number : 5 
Publishing Year : 1435 AH
2014 AD 
Article Type : Article 
Added Date : Tuesday, March 8, 2016 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Ananda MirchandaniMirchandani, Ananda Investigator  
Anne-Gaelle BesnardBesnard, Anne-Gaelle Researcher  
Edwin YipYip, Edwin Researcher  
Charlotte ScottScott, Charlotte Researcher  
Calum C BainBain, Calum C Researcher  
Vuk CerovicCerovic, Vuk Researcher  
Robert J SalmondSalmond, Robert J Researcher  
Foo Y LiewLiew, Foo Y Researcher  

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