Document Details

Document Type : Thesis 
Document Title :
DNA Fragmentation and Calcium Homeostasis in Relation to Antioxidative Status of Chemically-Induced Diabetic Rats
تجزيء الحامض النووي الديؤكسي ريبوزي وتوازن الكالسيومِ وعلاقتهم بحالة مضادات الأكسدة في مرض السكّري المستحثِّ كيميائيا في الجرذانِ
 
Subject : Faculty of Sciences > Biochemistry department 
Document Language : Arabic 
Abstract : Diabetes mellitus is a group of metabolic diseases characterized by high levels of blood sugar (hyperglycemia). The complications associated with diabetesare often responsible for a decreased quality of health in many patients. Reactive oxygen species can attack all types of macromolecules including DNA and damage them. DNA integrity and function can be affected by calcium overload and oxidative stress thus leading to cellular dysfunction and even cell death. This study was planned to evaluate calcium homeostasis in relation to cellular DNA damage in diabetic rats. This evaluation includes the difference of using alloxan and STZ as diabetic chemicals causing oxidative stress. Determination of the antioxidant status and its relation to body calcium homeostasis was also made. Sixtythree male Wister albino rats weighing 200±5 g, four to five weeks old used in this study. The experimental animals were divided into seven groups: control, diabetic, calcium-administered, calcium-administered (before or after) alloxan and calcium-administered (before or after) streptozotocin (STZ).The results showed that administration of calcium to diabetic rats has certain effective role on glucose level, liver function, kidney function, mineral levels, T3 and T4 hormones, lipid peroxidation and antioxidant status in hepatic tissues. This role depends in part on the timing of ca administration whether given before or after induction of diabetes and/or on the chemicals used for induction of diabetes. In general, although Ca homeostasis is considered as a critical factor in many body functions, the improvement of most functions of diabetic rats by Ca supplementation is not clearly declared especially when STZ was used for induction of diabetes. Therefore, further study may be required to verify these results in other organ tissues along with using various levels of calcium. 
Supervisor : Prof. Magdy Ahmed Ghoneim 
Thesis Type : Master Thesis 
Publishing Year : 1436 AH
2015 AD 
Added Date : Tuesday, June 9, 2015 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
فارس عبدالله الطوبAl Toub, Faris AbdullahResearcherMaster 

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