Document Details

Document Type : Article In Journal 
Document Title :
Mammal toxicity and mutagenicity assessment of the methanol extract of the molluscicidal plant Euphorbia schimperiana
Mammal toxicity and mutagenicity assessment of the methanol extract of the molluscicidal plant Euphorbia schimperiana
 
Subject : Biological 
Document Language : English 
Abstract : In this study, the toxic and mutagenic effects of Euphorbia schimperiana-methanol extract were investigated in Swiss albino mice of both sexes. In the course of a toxicological evaluation of this extract and prior to field applications, selected acute toxicity tests (oral, dermal, skin and eye irritation) were firstly determined. Then, three doses of acute oral (maximum, half maximum and double maximum) were chosen for the assessment of mutagenicity using the micronucleus test. While, the tested extract was slightly toxic non, irritant to the skin and moderately irritant to the ocular tissue it significantly increased the frequency of micro-nuclei particularly at the doubly maximum dose in both sexes. In conclusion, the results indicated that the Euphorbia schimperiana-methanol extract has slightly toxic effect. But has a potent mutagenic effect in mice. 
ISSN : 1028-8880 
Journal Name : Pakistan Journal of Biological Sciences 
Volume : 9 
Issue Number : 10 
Publishing Year : 1427 AH
2006 AD 
Article Type : Article 
Added Date : Wednesday, December 28, 2011 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Ekram S AhmedAhmed, Ekram SResearcherDoctorate 
ناجية عبدالخالق الزنبقيAl-Zanbagi, Najia AResearcherDoctoratenalzanbagi@gmail.com

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