تفاصيل الوثيقة
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نوع الوثيقة |
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مقال في مجلة دورية |
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عنوان الوثيقة |
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Modulatory effect of cod-liver oil on Na+-K+ ATPase in rats' brain Modulatory effect of cod-liver oil on Na+-K+ ATPase in rats' brain |
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الموضوع |
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كيمياء حيوية |
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لغة الوثيقة |
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الانجليزية |
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المستخلص |
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Omega-3 fatty acids were used in the treatment of psychiatric diseases such as bipolar disorder. Na+, K+-ATPase is also a well-known target for these fatty acids. In this study, we investigated the impact of cod-liver oil (CLO), docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on Na+, K+-ATPase, cholinesterase activities, the levels of norepinephrine (NE) and acetylcholine in different regions of rat brain. Our results showed that DHA caused a significant depression in cerebellum Na +, K+-ATPase, whereas CLO activated it. In addition, CLO, EPA and DHA produced a significant activation in Na+, K +-ATPase activity in medulla, midbrain and hypothalamus. There were non-significant changes in the activity of cholinesterase enzyme in cerebellum and medulla, while in midbrain and hypothalamus the CLO, DHA and EPA enhanced the activity by 75%, 100% and 78%, respectively. The content of NE in hypothalamus showed slight increase in different regions of the brain of animals fed CLO, DHA or EPA. In conclusion, CLO, DHA or EPA supplementation had a beneficial effect that associated with a normalization of fatty acids incorporation into phospholipid membranes and a partial restoration of Na +, K+-ATPase activity, suggesting that CLO supplementation may improve fatty acid composition and moderately enhance Na+, K+-ATPase activity. |
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ردمد |
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0960-3271 |
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اسم الدورية |
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Human and Experimental Toxicology |
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المجلد |
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30 |
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العدد |
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4 |
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سنة النشر |
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1432 هـ
2011 م |
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نوع المقالة |
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مقالة علمية |
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تاريخ الاضافة على الموقع |
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Wednesday, February 15, 2012 |
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الباحثون
| طه عبدالله قمصاني | Kumosani, Taha Abdullah | باحث | دكتوراه | tkumosani@kau.edu.sa |
| سعيد سلامة مصيلحي | Moselhy, Said S | باحث | دكتوراه | Moselhy6@hotmail.com |
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الرجوع إلى صفحة الأبحاث
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