تفاصيل الوثيقة

نوع الوثيقة : مقال في مجلة دورية 
عنوان الوثيقة :
ii-Preliminary Study in Diagnosis and Early Prediction of Preeclampsia by Using FTIR Spectroscopy
ii-Preliminary Study in Diagnosis and Early Prediction of Preeclampsia by Using FTIR Spectroscopy
 
الموضوع : كيمياء حيوية 
لغة الوثيقة : الانجليزية 
المستخلص : Preeclampsia is a heterogeneous condition, potentially involving several separate pathophysiological pathways; currently no clinical screening test is useful for prediction of preeclampsia development. Fouriertransform infrared spectroscopy (FTIR) holds great promise for clinical chemistry measurements. FTIR spectra of plasma samples from pregnant women -14 patients and 31 normotensive were obtained. Second derivative spectra, Kramer Krong refractive index and ANOVA test were tacking in comparison studies. The parameters studied were proteins and lipids. Different absorbance ratios for specific bands were calculated and plotted versus the patient samples. The absorbance IR spectra of these two groups were slightly different, but from the curve fitting analysis, the protein secondary structure compositions were significant different. The decrease in á-helix structure due to oxidative stress in patient group might be responsible of the dramatic increase in â- turns and unordered structure. Moreover, the peaks present in the IR second derivative, for patient group, at 1744cm-1 (cholesterol and triglycerides ester C=O), 1710cm-1 (carbonyl C-O stretch), and 1621cm-1 (peptide C=O stretch) positively correlated with low density lipoprotein (LDL) oxidation. The results showed that among the normotensive control group three subjects later developed preeclampsia. Normotensive pregnant women who developed preeclampsia were considered as subjects at high risk. This study suggests, for the first time that FT-IR spectroscopy can be successfully used as an accurate and rapid test, for diagnosis and confirmed with 33% confidence level early prediction of preeclampsia, starting from 20 week of gestation. 
ردمد : 1545-1003 
اسم الدورية : Journal of American Science 
المجلد : 7 
العدد : 4 
سنة النشر : 1432 هـ
2011 م 
نوع المقالة : مقالة علمية 
تاريخ الاضافة على الموقع : Monday, December 26, 2011 

الباحثون

اسم الباحث (عربي)اسم الباحث (انجليزي)نوع الباحثالمرتبة العلميةالبريد الالكتروني
جيهان عبدالرؤوفA. Raouf, Gehan باحثدكتوراهgehan_raouf@hotmail.com
عبدالرحمن لبيد المالكيAl-Malki, Abdulrahman Lباحثدكتوراهalalmalki@kau.edu.sa
نسمه منصوريMansouri, Nesma باحثدكتوراهnmansouri@kau.edu.sa
رقية محمد المحموديAl-Mahmoudi, Rogaia Mباحثماجستير 

الملفات

اسم الملفالنوعالوصف
 31781.pdf pdfAbstract

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