تفاصيل الوثيقة

نوع الوثيقة : مقال في مجلة دورية 
عنوان الوثيقة :
Impact of hypertension, smoking and liver affection on endothelial dysfunction and subsequent vascular damage in Saudi middle aged males patients
Impact of hypertension, smoking and liver affection on endothelial dysfunction and subsequent vascular damage in Saudi middle aged males patients
 
الموضوع : كيمياء حيوية 
لغة الوثيقة : الانجليزية 
المستخلص : Endothelial dysfunction is one of the mechanisms linked to an increased risk of cardiovascular disease. To assess the impact of hypertension, smoking and past history of schistosomiasis on endothelial dysfunction and vascular damage in Saudi middle aged males who don't exercise regularly, the levels of soluble adhesion molecules E-selectin, ICAM-1 and VCAM-1, biomarkers of the activation of inflammatory cascades during the development of vascular injury, were determined. Plasma levels of sVCAM-1, sICAM-1 and sE-selectin were found to be elevated as a result of hypertension and/or cigarette smoking compared to normal counterparts. These results demonstrated that hypertension and cigarette smoking had the strongest direct associations with these biomarkers which are a reflection of their effect on endothelial dysfunction and subsequent vascular damage, while a past history of schistosomiasis had very little association with these biomarkers. These results also suggest that sVCAM-1 may be useful in assessing the impact of liver affliction, (as a result of schistosomiasis) on endothelial dysfunction. 
ردمد : 1214-021X 
اسم الدورية : Journal of Applied Biomedicine 
المجلد : 5 
العدد : 4 
سنة النشر : 1428 هـ
2007 م 
نوع المقالة : مقالة علمية 
تاريخ الاضافة على الموقع : Saturday, December 17, 2011 

الباحثون

اسم الباحث (عربي)اسم الباحث (انجليزي)نوع الباحثالمرتبة العلميةالبريد الالكتروني
خالد عمر أبو النجاAbulnaja, Khalid Oباحثدكتوراهkabualnaja@kau.edu.sa

الملفات

اسم الملفالنوعالوصف
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