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نوع الوثيقة |
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مقال في مجلة دورية |
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عنوان الوثيقة |
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Protective effects of Nigella sativa oil on propoxur-induced toxicity and oxidative stress in rat brain regions Protective effects of Nigella sativa oil on propoxur-induced toxicity and oxidative stress in rat brain regions |
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الموضوع |
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كيمياء حيوية |
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لغة الوثيقة |
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الانجليزية |
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المستخلص |
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Propoxur (PPr) is a widely used broad spectrum carbamate insecticide mainly used to control household pests. Because of the widespread use of pesticides for domestic and industrial applications, evaluation of their neurotoxic effects is of major concern to public health. The aim of the present study was to evaluate the possible protective effects of Nigella sativa oil (NSO), an antioxidant agent, against PPr-induced toxicity and oxidative stress in different brain regions of rats including cerebellum, cortex and hippocampus. In the present study, 32 male Sprague-Dawley rats were used and divided into four equal groups. Group 1 was allocated as the control group. Groups 2-4 were orally administered 1. ml/kg/bw/day NSO, 8.51. mg/kg/bw/day PPr or NSO plus PPr, respectively, for 30. days. Lipid peroxidation (LPO), protein carbonyl content (PCC) and acetylcholine esterase activity (AChE) were determined. Enzymatic antioxidant activities [superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione-S-transferase (GST)] and non-enzymatic antioxidants [reduced glutathione (GSH)] were determined. PPr treatment significantly increased the levels of LPO, PCC and oxidized glutathione (GSSG) in brain regions. On the contrary, levels of GSH and the activities of SOD, CAT, GSH-Px, GST and AChE were significantly decreased. NSO treatment to PPr intoxicated rats restored such biochemical parameters to within control levels except GST activity, emphasizing its antioxidant role. We conclude that NSO significantly reduces PPr-induced toxicity and oxidative stress in rat brain regions via a free radicals scavenging mechanism. |
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ردمد |
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0048-3575 |
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اسم الدورية |
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Pesticide Biochemistry and Physiology |
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المجلد |
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98 |
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العدد |
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1 |
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سنة النشر |
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1431 هـ
2010 م |
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نوع المقالة |
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مقالة علمية |
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تاريخ الاضافة على الموقع |
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Tuesday, October 18, 2011 |
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الباحثون
| أحمد محمدين | Mohamadin, Ahmed | باحث | دكتوراه | amohamadin@yahoo.com |
| Bassem Sheikh | Sheikh, Bassem | باحث | دكتوراه | |
| Amany A Abd El-Aal | Abd El-Aal, Amany A | باحث | دكتوراه | |
| Ahmed A Elberry | Elberry, Ahmed A | باحث | دكتوراه | |
| فهد أحمد العباسي | Al-Abbasi, Fahad A | باحث | دكتوراه | alabassif@hotmail.com |
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