تفاصيل الوثيقة نوع الوثيقة : مقال في مجلة دورية  عنوان الوثيقة : Are women at an increased risk of gestational thyrotoxicosis Are women at an increased risk of gestational thyrotoxicosis   الموضوع : النساء والولادة  لغة الوثيقة : الانجليزية  المستخلص : OBJECTIVE: To evaluate the relative importance of thyroid hormones and human chorionic gonadotropin in relation to the risk of gestational thyrotoxicosis in Saudi women living in Jeddah, Kingdom of Saudi Arabia. METHODS: A prospective study was conducted on Saudi healthy pregnant women (N=406) at 12-15 weeks of gestation and compared with healthy non-pregnant controls (N=200). Maternal serum levels of free thyroxine free triiodothyronine, thyrotropin, human chorionic gonadotropin and free b-human chorionic gonadotropin together with urinary iodine excretion were determined. Analysis of variance was used to examine differences among the groups for different variables and the Bonferroni criterion was used when significance tests were made. RESULTS: Pregnant women were classified into 2 groups according to the lower limit of serum thyrotropin levels in non-pregnant euthyroid controls at >= 0.3 mIU/L (Group one) or < 0.30 mIU/L (Group 2). Suppressed levels of serum thyrotropin (< 0.30 mIU/L) were found in 11.1% of pregnant women which was accompanied by significant increases in free thyroxine (P<0.001), free triiodothyronine (P < 0.05), human chorionic gonadotropin (P<0.001) and b-human chorionic gonadotropin (P<0.001). A significant negative correlation between serum levels of thyrotropin and that of human chorionic gonadotropin (r=-0.381, P<0.001) was observed. The relative risk of having a serum thyrotropin level of < 0.30 mIU/L was 4.89 (P<0.001) for the pregnant women examined as compared with non-pregnant controls. Approximately 5.6% of the women examined exhibited biochemical evidence of thyrotoxicosis. CONCLUSION: The results of the present study show that Saudi pregnant women are at risk of developing biochemical evidence of thyrotoxicosis during early gestation, and thus, are likely to be at greater risk of clinically evident gestational thyrotoxicosis and hyperemesis gravidarum. Genetically determined differences in the synthesis or metabolism of human chorionic gonadotropin isoforms, or both may contribute to this increased risk  ردمد : 0379-5284  اسم الدورية : المجلة الطبية السعودية  المجلد : 23  العدد : 6  سنة النشر : 1423 هـ 2002 م  نوع المقالة : مقالة علمية  تاريخ الاضافة على الموقع : Sunday, April 3, 2011  الباحثون اسم الباحث (عربي) اسم الباحث (انجليزي) نوع الباحث المرتبة العلمية البريد الالكتروني محمد العرضاوي Ardawi, Mohammed باحث رئيسي دكتوراه   حسن نصرت Nasrat, Hasan باحث مشارك دكتوراه   عبدالرحيم روزي Rouzi, AbdulRahim باحث مشارك دكتوراه   الملفات اسم الملف النوع الوصف  29497.pdf pdf   الرجوع إلى صفحة الأبحاث