تفاصيل الوثيقة نوع الوثيقة : مقال في مجلة دورية  عنوان الوثيقة : التشخيص الخاطئ لشد وتوتر العضلات Misdiagnoses in Children with Dopa-responsive Dystonia.   لغة الوثيقة : الانجليزية  المستخلص : Dystonia is a state of continuous contraction of groups of agonist and antagonist muscles resulting in a sustained abnormal posture. Dopa-responsive dystonia was first described in 1976 by Segawa. Patients typically have diurnal variation of their symptoms with worsening at the end of the day and a dramatic response to low dose L-dopa. This paper presents five consecutive children with dopa-responsive dystonia who were misdiagnosed initially as spastic diplegic cerebral palsy, intractable epilepsy, hereditary spastic paraplegia, or a neurodegenerative disorder. There were 2 males and 3 females aged 3-13 years (mean 8.6). They were followed for up to 2 years (mean 14.8 months). One had focal, 1 axial, 1 segmental, and 2 generalized dystonia. The dystonia was paroxysmal in 2 (tiptoe walking and opisthotonus) and all had a progressive course. All children responded dramatically to L-dopa (mean 200 mg/day) including 3 who were wheelchair bound for several years. The difficulties in early diagnosis, variability of clinical presentation, and dramatic response to L-dopa will be illustrated. To conclude, dopa-responsive dystonia should be considered in any child who presents with paroxysmal or progressive hypertonia of unknown etiology because it responds so dramatically to L-dopa.  ردمد : 0379-5284  اسم الدورية : Pediatric Neurology  المجلد : 4  العدد : 31  سنة النشر : 2004 هـ 2004 م  نوع المقالة : مقالة علمية  تاريخ الاضافة على الموقع : Saturday, March 13, 2010  الباحثون اسم الباحث (عربي) اسم الباحث (انجليزي) نوع الباحث المرتبة العلمية البريد الالكتروني محمد جان jan, Mohammed باحث دكتوراه   الملفات اسم الملف النوع الوصف  25915.doc doc   الرجوع إلى صفحة الأبحاث