تفاصيل الوثيقة نوع الوثيقة : مقال في مجلة دورية  عنوان الوثيقة : الطفح الجلدى الناتج من علاج الاميكتال Potentially Serious Lamotrigine-Related Skin Rash.   لغة الوثيقة : الانجليزية  المستخلص : Background: Lamotrigine (LTG) can be associated with an idiosyncratic, immune mediated, hypersensitivity skin rash. It can evolve to Stevens-Johnson syndrome (SJS), particularly if used with valproic acid (VPA). Our objective is to report our experience with LTG-related skin rash in children with epilepsy. Methods: Series of consecutive children with epilepsy treated with LTG were identified prospectively over a 5-year period ending 1/10/2005 at King Abdulaziz University Hospital and King Faisal Specialist Hospital and Research center, Jeddah, Saudi Arabia. Follow up by one neurologist was performed. Results: Of 207 children on LTG, 15 (7.2%) developed a skin rash with ages ranging between 3-12 years (mean 7.5). LTG was used as monotherapy in 3/15 and as add on in 12/15, mostly (10/15) in addition to VPA. The rash was mild with complete recovery in 7 children (47%). The remaining 8 (3.9% of the total) had severe rash that necessitated admission to hospital. Seven out of these 8 children were also receiving VPA. One child had superimposed secondary bacterial infection and admitted for intravenous antibiotics. Two children recovered slowly with extensive post-inflammatory hyperpigmentation. SJS was diagnosed in 5 children (2.4% of the total). One of these 5 children had progressive symptoms that evolved to toxic epidermal necrolysis. He required prolonged intensive care admission and developed sepsis with disseminated intravascular coagulopathy. He deteriorated despite of supportive therapy and died 5 weeks after the initiation of LTG therapy. Conclusions: Lamotrigine is a novel antiepileptic drug with a favorable therapeutic profile and good tolerability. LTG-related skin rash is a potentially serious adverse event that should be carefully monitored. Although the risk is small, it should be weighed against the potential benefits, particularly in children on VPA.  ردمد : 0379-5284  اسم الدورية : Neurosciences Journal  المجلد : 1  العدد : 12  سنة النشر : 2007 هـ 2007 م  نوع المقالة : مقالة علمية  تاريخ الاضافة على الموقع : Saturday, March 13, 2010  الباحثون اسم الباحث (عربي) اسم الباحث (انجليزي) نوع الباحث المرتبة العلمية البريد الالكتروني محمد جان jan, Mohammed باحث دكتوراه   الملفات اسم الملف النوع الوصف  25895.doc doc   الرجوع إلى صفحة الأبحاث