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نوع الوثيقة |
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مقال في مجلة دورية |
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عنوان الوثيقة |
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The influence of smoking on semen quality, seminal microelements and Ca2+-ATPase activity among infertile and fertile men The influence of smoking on semen quality, seminal microelements and Ca2+-ATPase activity among infertile and fertile men |
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الموضوع |
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كيمياء حيوية |
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لغة الوثيقة |
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الانجليزية |
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المستخلص |
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Objective: Tobacco smoking is now increasing rapidly throughout the developing world and is one of the biggest threats to current and future world health. Several studies have addressed the role of cigarette smoking on semen quality, but the exact mechanisms remain inconclusive. In order to evaluate the detrimental effects of smoking on semen quality among Saudi subjects, the levels of different seminal parameters in smokers were compared to non-smokers. Patients and methods: A total of 159 semen samples (61 smokers and 98 non-smokers) from men attending an infertility clinic for routine infertility workup were sub-grouped into fertile or infertile and were compared based on standard semen analysis (according to WHO guidelines), content of metals (magnesium, zinc and cadmium) and plasma membrane Ca2+-ATPase activity of sperms. Results: Cadmium concentration was found significantly higher in smokers than in non-smokers either in fertile or infertile group (2.9 ± 0.4 vs 1.4 ± 0.7; 2.9 ± 0.5 vs 1.3 ± 0.7 μg L- 1; respectively). Together with this increase in seminal Cd a significant decrease in Ca2+-ATPase activity (21.5 ± 2.8 vs 33.71 ± 1.2; 20.7 ± 1.5 vs 35.07 ± 2.9 mmol min- 1 mg- 1 protein, p < 0.05), decrease in seminal zinc (109.8 ± 8.1 vs 189.7 ± 9.9 mg L- 1, p < 0.01) and decrease in sperm motility (41.9% ± 2.9 vs 46.01% ± 2.5; 9.8% ± 2.4 vs 15.3% ± 2.7, p < 0.05) were found. Conclusion: Our data demonstrate that cigarette smoking affects both Ca2+-ATPase activity and motility of the spermatozoa. These effects may be attributed to increased seminal cadmium and reduced zinc concentrations. © 2008 The Canadian Society of Clinical Chemists. |
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ردمد |
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0009-9120 |
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اسم الدورية |
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Clinical Biochemistry, Volume 41, Issue 14-15, October 2008, Pages 1199-1203 |
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المجلد |
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41 |
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العدد |
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14 |
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سنة النشر |
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2008 هـ
2008 م |
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عدد الصفحات |
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4 |
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نوع المقالة |
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مقالة علمية |
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تاريخ الاضافة على الموقع |
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Thursday, October 15, 2009 |
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الباحثون
| طه عبدالله طه قمصاني | Taha A. Kumosani | باحث | دكتوراه | tkumosani@kau.edu.sa |
| محمد فاروق عبدالله الشال | Mohamed Farouk Abdallah Elshal | باحث | دكتوراه | melshal2002@yahoo.com |
| Al-Jonaid, A.A | Al-Jonaid, A.A | باحث | دكتوراه | |
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