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نوع الوثيقة |
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مقال في مجلة دورية |
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عنوان الوثيقة |
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Melatonin for the Treatment of Handicapped Children With Severe Sleep Disorders Melatonin for the Treatment of Handicapped Children With Severe Sleep Disorders |
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لغة الوثيقة |
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الانجليزية |
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المستخلص |
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Sleep disorders are common in children with mental
retardation and neurologic disorders. Melatonin, a
recently developed natural compound, has been used
successfully in sleep disorders. I report my experience
with melatonin in an open, prospective trial to treat
circadian rhythm sleep disorder in handicapped children.
The sleep disorder had been present for at least
6 months and had not responded to at least one
hypnotic drug. The therapeutic response was recorded
according to the average number of hours asleep per
24 hours, average number of awakening per night,
average number of nights with delayed sleep onset, and
average number of nights with early morning arousals.
Ten consecutive children (four males, six females; age
range 5 1-11 years, mean 5.4) were included. Nine
children had documented mental retardation that was
severe in six (67%). Most had epilepsy and visual
impairment (70%). All children were monitored for
4-12 months (mean 7.5 months) after the initiation of
3-mg bedtime melatonin. Most (80%) had a dramatic
response to melatonin. No side effects were reported.
Melatonin is a well-tolerated, safe, relatively inexpensive,
and effective drug, with minimal side effects, for
the treatment of severe circadian rhythm sleep disorder
in handicapped children. Wider use of this drug is
recommended. © 2000 by Elsevier Science Inc. All
rights reserved |
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ردمد |
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0887-8994 |
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اسم الدورية |
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Pediatric Neurology |
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المجلد |
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23 |
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العدد |
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3 |
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سنة النشر |
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1421 هـ
2000 م |
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نوع المقالة |
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مقالة علمية |
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تاريخ الاضافة على الموقع |
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Saturday, March 22, 2008 |
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الباحثون
| محمد جان | Jan, Mohammed | باحث | دكتوراه | |
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